The use of rosuvastatin and alpha lipoic acid in patients with unstable angina

  • E.H. Zaremba The Danylo Halytsky National Medical University in Lviv
  • O.V. Smalyukh The Danylo Halytsky National Medical University in Lviv
  • O.V. Zaremba-Fedchyshyn The Danylo Halytsky National Medical University in Lviv
  • O.V. Zaremba The Danylo Halytsky National Medical University in Lviv
Keywords: unstable angina, rosuvastatin, alpha lipoic acid, blood lipid profile

Abstract

Aim. To investigate the blood lipid profile, indices of functional condition of the liver in patients with unstable angina in the treatment of statins in combination with alpha lipoic acid. 

Material and Methods. 61 patients (21 males and 40 females) with unstable angina have been examined. Patients' average age was 68.3±11.3. Patients were divided into 2 groups due to therapeutic management. Patients of the first group received conventional therapy according to the standards required with necessarily intake of statins; patients of the second group received alpha lipoic acid in combination with conventional therapy. 20 almost healthy individuals of appropriate age and gender comprised the control group. To assess blood lipid spectrum were determined: total cholesterol, low-density lipoprotein cholesterol lipoprotein very low density, high-density lipoprotein cholesterol, triglycerides, atherogenic ratio by conventional methods. Functional status was evaluated by determining hepatic levels of total bilirubin and transaminases. Statistical analysis was done using Microsoft Exel and Statistica 6.0 statistical analysis method definition Student t-test.

Results and Discussion. In patients with unstable angina compared with the control group before treatment revealed a significant increase in total cholesterol, low-density lipoprotein cholesterol, lipoprotein cholesterol very low density, triglycerides and the atherogenic factor. Levels of bilirubin, transaminases did not differ from that of the control group. After treatment in both groups revealed a significant decrease in total cholesterol, low-density lipoprotein cholesterol, lipoprotein cholesterol of very low density, triglycerides. The results indicate hypolipidemic effect of statins and correspond to the results of other authors. The level of total bilirubin after treatment in both groups did not change. In the first group of patients after treatment was improving by 29.7% aspartate aminotransferase, alanine aminotransferase 24.6%. In the group of patients taking rosuvastatin in combination with alpha-lipoic acid after treatment revealed a marked reduction in total cholesterol by 8.6%, low-density lipoprotein cholesterol by 13% atherogenic ratio of 14% (p<0.05) as compared to patients taking rosuvastatin. Treatment of patients with unstable angina statin in combination with alpha-lipoic acid did not significantly affect the level of transaminase levels. Comprehensive treatment of unstable angina rosuvastatin with alpha-lipoic acid improves hypolipidemic effect of statins has a positive effect on the functional state of the liver.

Conclusions. Rosuvastatin combined with alpha-lipoic acid leads to a significant normalization of lipid profile compared to just taking rosuvastatin. Alpha lipoic acid prevents the negative effect of statins on the functional state of the liver.

References

Gandzyuk V.A.: Analysis of ischemic heart disease morbidity in Ukraine. Ukrainian Cardiology Journal 2014; 3: 45-52.

Kovalenko V. M., Dorogoi A.P. Cardivascular disease : medical and social value and strategy of cardiology in Ukraine. Ukrainian Cardiology Journal 2016; Supplement 3: 5-14.

Mishchenko L.A.: The effectiveness of rosuvastatin (Klivas) in patients with coronary heart disease (the results of the prospective study "clean vessels". Ukrainian Medical Journal 2016; 3 (13): 98-100.

Kotseva K., Wood D., De Backer G., Ryd?n L. et al.: EUROASPIRE Investigators (2016) EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. European journal of preventive cardiology 2016, 23(6), 636-648. https://doi.org/10.1177/2047487315569401

Olsson A.G.: Rosuvastatinin dyslipidaemia and coronary heart disease. Science Press. 2004, 1, 71-77.

Stadnik S.M.: Rosuvastatin: New Opportunities for Treatment of Atherosclerosis. Medicine of Ukraine 2015; 4 (190):38-41.

Bugaenko V.V. Statins in primary and secondary prevention of cardiovascular risk: а new look at old problem. Ukrainian Cardiology Journal 2014; 3: 103-107.

Athyros V.G., Mikhailidis D.P., Didangelos T.P., Giouleme OI, Liberopoulos EN, Karagiannis A, Kakafika AI, Tziomalos K, Burroughs AK, Elisaf MS.: Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrom: a randomised study. Current medical research and opinion 2006, 22, 873-883. https://doi.org/10.1185/030079906X104696

Bays H.: Statin safety: an overview and assessment of the data-2005. The American journal of cardiology 2006, 97, 6-26. https://doi.org/10.1016/j.amjcard.2005.12.006

Cohen L.H., Anania F.A., Chalasani N.: An assessment of statin safety by hepatologists. The American journal of cardiology 2006, 97, 77-81. https://doi.org/10.1016/j.amjcard.2005.12.014

Zaremba E.H., Smalyukh O.W. The effect of statins in combination with alpha-lipoic acid on the function of the liver in liver in patients with unstabile angina. Medical matter. 2016; 4(50): 47-49.

Putintseva V.I., Chernikov N.M., Lobachevskaya T.A. and others. Some aspects of application lypoevoy acid (berlytyona) in the Treatment of Chronic toxic hepatitis. Art therapy. 2005; 1: 98-100.

Vasdev S., Ford C.A., Parai S., Longerich L., Gadag V.: Dietary alpha-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats. Journal of Hypertension 2000, 18 (5), 567-573. https://doi.org/10.1097/00004872-200018050-00009

Wray D.W., Nishiyama S.K., Harris R.A.: Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension 2012, 59 (4), 818-824. https://doi.org/10.1161/HYPERTENSIONAHA.111.189456

Scherbak A.V.: Recent situation in pharmaceutical market of medical preparations of alfa-lipoic acid in Ukraine. Farmatsevtychnyi zhurnal 2000; 4:29-32.

Schulpecova J.O., Ivashkin V.T.: Application tyoktovoy acid in gastroenterology. Russian Medical Journal 2000; 15, 630.

Bilovol A.N., Knyazkova I.I.: Alpha-lipoic acid: from pharmacological properties to clinical application. Medicine of Ukraine 2015; 7:4-10.

Gomes M.B., Negrato C.A. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic disease. Diabetology and Metabolic Syndrome 2014, 6, 80. https://doi.org/10.1186/1758-5996-6-80

Published
2017-04-21
How to Cite
Zaremba, E., Smalyukh, O., Zaremba-Fedchyshyn, O., & Zaremba, O. (2017). The use of rosuvastatin and alpha lipoic acid in patients with unstable angina. Acta Medica Leopoliensia, 23(1-2), 9-14. https://doi.org/10.25040/aml2017.01.009