The use of rosuvastatin and alpha lipoic acid in patients with unstable angina
Aim. To investigate the blood lipid profile, indices of functional condition of the liver in patients with unstable angina in the treatment of statins in combination with alpha lipoic acid.
Material and Methods. 61 patients (21 males and 40 females) with unstable angina have been examined. Patients' average age was 68.3±11.3. Patients were divided into 2 groups due to therapeutic management. Patients of the first group received conventional therapy according to the standards required with necessarily intake of statins; patients of the second group received alpha lipoic acid in combination with conventional therapy. 20 almost healthy individuals of appropriate age and gender comprised the control group. To assess blood lipid spectrum were determined: total cholesterol, low-density lipoprotein cholesterol lipoprotein very low density, high-density lipoprotein cholesterol, triglycerides, atherogenic ratio by conventional methods. Functional status was evaluated by determining hepatic levels of total bilirubin and transaminases. Statistical analysis was done using Microsoft Exel and Statistica 6.0 statistical analysis method definition Student t-test.
Results and Discussion. In patients with unstable angina compared with the control group before treatment revealed a significant increase in total cholesterol, low-density lipoprotein cholesterol, lipoprotein cholesterol very low density, triglycerides and the atherogenic factor. Levels of bilirubin, transaminases did not differ from that of the control group. After treatment in both groups revealed a significant decrease in total cholesterol, low-density lipoprotein cholesterol, lipoprotein cholesterol of very low density, triglycerides. The results indicate hypolipidemic effect of statins and correspond to the results of other authors. The level of total bilirubin after treatment in both groups did not change. In the first group of patients after treatment was improving by 29.7% aspartate aminotransferase, alanine aminotransferase 24.6%. In the group of patients taking rosuvastatin in combination with alpha-lipoic acid after treatment revealed a marked reduction in total cholesterol by 8.6%, low-density lipoprotein cholesterol by 13% atherogenic ratio of 14% (p<0.05) as compared to patients taking rosuvastatin. Treatment of patients with unstable angina statin in combination with alpha-lipoic acid did not significantly affect the level of transaminase levels. Comprehensive treatment of unstable angina rosuvastatin with alpha-lipoic acid improves hypolipidemic effect of statins has a positive effect on the functional state of the liver.
Conclusions. Rosuvastatin combined with alpha-lipoic acid leads to a significant normalization of lipid profile compared to just taking rosuvastatin. Alpha lipoic acid prevents the negative effect of statins on the functional state of the liver.
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